Targeted Drug Delivery in Alzheimer's Disease: Novel Systems and Strategies for Improved Cognitive Health

Abstract

Alzheimer’s disease (AD) presents significant challenges in therapeutic management due to complexities in drug delivery. Traditional methods often fall short in addressing critical issues such as blood-brain barrier (BBB) penetration, drug stability, and precise targeting, which are crucial for effective treatment. This mini-review explores the current limitations in drug delivery for
Alzheimer's disease and evaluates novel systems designed to overcome these hurdles. Recent advancements in drug delivery technologies, such as nanoparticles, liposomes, and nanocarriers, are highlighted for their potential to enhance targeted delivery to the brain. These systems offer improved BBB penetration and increased drug stability, which can lead to more effective and sustained therapeutic effects. Additionally, the review discusses various strategies employed to optimize drug delivery and improve cognitive health in AD patients. Techniques focusing on targeting specific brain regions, reducing systemic side effects, and enhancing overall drug efficacy are examined. By addressing these challenges with innovative delivery systems and strategic advancements, there is significant potential to improve patient outcomes and cognitive function. This review underscores the importance of continued research and development in drug delivery technologies to address the complexities of Alzheimer’s disease and to provide more effective and personalized treatment options.