Overcoming the Blood-Brain Barrier: Liposome Strategies for Treating Brain Tumors

Abstract

Brain tumors present a significant therapeutic challenge due to the protective blood-brain barrier (BBB), which impedes the delivery of conventional treatments. Liposome-based drug delivery systems offer a promising solution to this issue by enhancing targeted drug delivery and improving BBB penetration. This review examines the design and optimization of liposomes for brain tumor targeting, focusing on innovations in surface modifications and drug encapsulation techniques that enhance the ability of liposomes to cross the BBB. It explores the mechanisms through which liposomes penetrate the BBB, including the physiological and biochemical processes involved in their interaction with brain tumor cells. Additionally, the review summarizes clinical applications and efficacy, highlighting recent studies and trials that assess the effectiveness of liposome-based therapies in treating various types of brain tumors. By providing insights into the current state of liposome technology in brain tumor treatment, this review aims to offer a comprehensive understanding of how these advanced drug delivery systems can overcome the challenges posed by the BBB and improve therapeutic outcomes.